Neuromodulation of dendrites
Many receptors for neuromodulators are located on dendrites affecting specific ionic currents that in turns shape synaptic integration. Recently we have focused on how norepinephrine affects the dendritic current Ih which is a key current in regulating the excitability of the apical tuft of layer 5 pyramidal neurons. We also explore the effect of dendritic neuromodulators on synaptic plasticity.