Neuromodulation of dendrites

Many receptors for neuromodulators are located on dendrites affecting  specific ionic currents that in turns shape synaptic integration. Recently we have focused on how norepinephrine affects the dendritic current Ih which is a key current in regulating the excitability of the apical tuft of layer 5 pyramidal neurons. We also explore the effect of dendritic neuromodulators on synaptic plasticity.  

The influence of acetylcholine (ACh) on the processing of sensory information is largely unknown. By perturbing the cholinergic system and applying various methods such as two-photon calcium imaging and electrophysiology in vivo, we can get new insights into its different roles. We believe that in order to understand how ACh is involved in the neural code, it is necessary to examine processing on various levels, from single cell to behavior.

The effect of ACh on sensory information processing

Ultrasonic vocalizations as a model system for temporal sequences

Mice emit complex sequences of ultrasonic vocalizations in various social contexts. We study the neural mechanisms underlying this behaviour in order to understand how does the brain generates and executes complex temporal sequences.   

The geometry of dendrites as well as the spectrum of ion channels they host allow them to actively participate in the integration of synaptic inputs. This may have important implication on they types of computations carried out by neurons. Currently we are using recent advances in deep learning to better understand dendritic computation

Dendritic computation

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Edmond and Lily Safra Center for Brain Sciences (ELSC) &
Alexander Silberman Life Science Institute
2103 Goodman Building
The Hebrew University
Safra Campus, Jerusalem 9190401

Israel

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